Bypass module

Bypass module - online dialysis sampling

The bypass dialysis module is an alternative to the dialysis probe.
It is frequently used for perfusion cultures and in other cases where in-situ sampling with the dialysis or filtration probe is not possible.

The bypass module is installed as a part of the perfusion tubing manifold outside of the bioreactor.

The bypass module stainless steel consists of three blocks which can be easily fixed and sealed by allen screws. The front block and the middle block are forming the donor-channel, which connects the flowing stream of reactor medium with the dialysis membrane. The rear block serves as the acceptor-channel and fixes the dialysis membrane with the middle block. The dialysis membrane creates a sterile barrier between the two channels and permits diffusion of the analyte into the acceptor stream. Two barbed tubing adapters for tubing I.D. up to 6 mm or I.D. 9 mm are used for the connection with the donor stream and UNF analytical fittings are used for the connection of the analyser manifold.
The bypass module stainless steel is used for larger volume flow rates of the donor stream.

 

The bypass module PEEK consists of two blocks which can be easily fixed and sealed by allen screws. The front block is forming the donor-channel, which connects the flowing stream of reactor medium with the dialysis membrane. The rear block serves as the acceptor-channel and fixes the dialysis membrane with the front block. The dialysis membrane creates a sterile barrier between the two channels and permits diffusion of the analyte into the acceptor stream. The bypass module PEEK is prepared with two pump tubing adapters for tubing I.D. 2 mm and two o-rings for the additional sealing of the adapter.
The bypass module PEEK is used for smaller volume flow rates of the donor stream.

Features

  • Sampling system for the online analyser TRACE C2 Control and MultiTRACE
  • Sterile online dialysis sampling
  • Installation outside of the bioreactor
  • Sterilisation in an autoclave

Advantages

  • Alternative to the dialysis probe
  • Online sampling in connection with an external pump for cell cultures
  • Robust dialysis membrane
  • Independent of the fermenter size
  • Recommended for viscous media and media with small solid particles
  • Can be used for fermentation processes with steam sterilisation
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