Publications

Implementation of a new method for online glucose control in a 10 L CHO bioprocess

More than 75% of recombinant therapeutic proteins are produced using mammalian cell culture process... read more

Presented at EuroPACT 2017 in Potsdam, Germany

Online Controlling of Glucose in Cultivations and Fermentations - demonstrated in Acetone Production with a recombinant E.coli

Glucose is used as substrate for many microbial and eukaryotic cells. In cell cultivations and microbial fermentations, the glucose concentrations has to be monitored... read more

Presented at ProcessNet Jahrestagung and 32. Dechema Jahrestagung der Biotechnologen 2016 in Aachen, Germany

Optimized fedbatch fermentation by use of online glucose measurement

Advanced process control with multivariate feeding strategies...read more

Presented at ProcessNet Jahrestagung and 32. Dechema Jahrestagung der Biotechnologen 2016 in Aachen, Germany

Process optimization by the use of substrate feeding strategies with an integrated online glucose measuring tool

In the biotechnological production of market-relevant industrial chemicals, fed- batch fermentation is a common method to obtain high cell densities and thus higher space-time yield. On this occasion, substrate supply is an important parameter for process regulation. Glucose is the most important substrate for microorganisms and animal cell lines in bioprocesses. Integrated glucose monitoring tool TRACE C2 Control is used to keep the substrate concentration on a defined level ... read more

Presented at BioProcessing Days 2016 in Recklinghausen, Germany

Online-Controlling of Glucose in Cultivations and Fermentations

Glucose is used as substrate for many microbial and eukaryotic cells. In cell cultivations and microbial fermentations the glucose concentration has to be monitored. Furthermore it is beneficial to control the glucose concentration on a certain level to reduce the formation of by-products. In most of the processes low glucose concentrations in the medium will be preferred ... read more

Presented at EuroPACT 2014 in Barcelona, Spain

Online-Ethanol and Online-Methanol Measurements in Fermentation Processes

Ethanol and methanol are products of various microorganisms. Depending on the process they can be main product, by-product, or can be used as inducer. In a lot of processes it is important to monitor the amount of ethanol or methanol in order to know the end point of the fermentation or to avoid a toxic concentration inside the fermentation broth. For some ... read more

Presented at the Frühjahrstagung der Biotechnologen 2013 in Frankfurt, Germany

 

On-line glucose measurement in disposable bioreactors

The use of disposables in biopharmaceutical processes has increased significantly during the last few years, both for improved performance and for the economic advantages they offer. However, there is a need for additional sensors that will enable the disposable process to be integrated in compliance with the latest Process Analytical Technologies. TRACE... read more

Presented at the Biopharmaceuticals 2010 in Benediktbeuern, Germany

 

 

Single-use bioreactor for high density bacterial fermentation

Single-use bioreactors have many advantages for R&D fermentation process development. Rapid system implementation, increased flexibility in size and turn-around, reduced infrastructure, reduced cross contamination risk and minimized maintenance requirement are main drivers... read more

Presented at the RPP6 conference University of BOKU 2011 in Vienna, Austria

Control of critical process parameters using in-situ analytics

How bioprocess engineers can improve control of their bioreactors using dedicated, real-time, on-line sensors...read more

Veröffentlichung: Bioprocess International 2017 by Dan Kopec, Sartorius Stedim Biotech

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